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Antitumor activity of Hypericum hookerianum against DLA induced tumor in mice and its possible mechanism of action
Author(s) -
Dongre Santoshkumar H.,
Badami Shrishailappa,
Godavarthi Ashok
Publication year - 2008
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2248
Subject(s) - pharmacology , in vivo , mechanism of action , ascites , body weight , cytotoxic t cell , antioxidant , medicine , tumor cells , pharmacognosy , traditional medicine , biology , biological activity , in vitro , cancer research , biochemistry , microbiology and biotechnology
A large number of plants belonging to the genus Hypericum and their phytoconstituents are known to possess potent anticancer nature. Earlier studies from our laboratories indicated a strong cytotoxic nature of the methanol extract of Hypericum hookerianum stem (MEHH). In the present study, the in vivo antitumor activity of MEHH against the Dalton's lymphoma ascitic (DLA) model was determined at 100 and 200 mg/kg body weight given orally for 10 days. The results indicate that administration of the extract not only increased the survival of animals with ascites tumor, decreased the body weight induced by the tumor burden and reduced the packed cell volume and viable tissue cell count, but also altered many hematological parameters changed during tumor progression indicating the potent antitumor nature of the extract. Hematological and biochemical analysis were carried out to prove the anticancer and antioxidant nature of the extract. Copyright © 2007 John Wiley & Sons, Ltd.