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Inhibitory effect of aerial parts of Scrophularia striata on matrix metalloproteinases expression
Author(s) -
Hajiaghaee Reza,
MonsefEsfahani Hamid R.,
Khorramizadeh Mohammad R.,
Saadat Farshid,
Shahverdi Ahmad R.,
Attar Farideh
Publication year - 2007
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2221
Subject(s) - matrix metalloproteinase , angiogenesis , extracellular matrix , inhibitory postsynaptic potential , cytotoxicity , cell culture , metastasis , scrophulariaceae , chemistry , matrix metalloproteinase inhibitor , pharmacology , biology , traditional medicine , biochemistry , cancer research , botany , medicine , cancer , in vitro , genetics , endocrinology
It has been shown that destruction of the extracellular matrix (ECM) by matrix metalloproteinases (MMPs) leads to tumor invasion, metastasis and angiogenesis. The aim of the present research was to verify the effects of a total extract and sequential extracts of Scrophularia striata Boiss (Scrophulariaceae) on MMPs activity. The fibro sarcoma cell line (wehi‐164) was used to assess MMPs inhibitory effect. The MMPs activity was evaluated using a zymoanalysis method. The results of this study showed that the highest MMPs inhibitory effect (55.6%) was observed after treatment with 10 µg/mL of the high polarity methanol solution extract corresponding to its lowest cytotoxicity effect (4%). It is concluded that the aerial parts of S. striata might contain various polar compounds that inhibit MMPs. Copyright © 2007 John Wiley & Sons, Ltd.