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Tumour preventive effect of Aloe vera leaf pulp lectin (Aloctin I) on Ehrlich ascites tumours in mice
Author(s) -
Akev Nuriye,
Turkay Gulhan,
Can Ayse,
Gurel Aydin,
Yildiz Funda,
Yardibi Hasret,
Ekiz Elif Ergul,
Uzun Hafize
Publication year - 2007
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2215
Subject(s) - aloe vera , spleen , lectin , red pulp , sialic acid , ascites , immunology , lymphoid hyperplasia , biology , ehrlich ascites carcinoma , pharmacology , medicine , pathology , traditional medicine , cancer research , lymphoma , biochemistry , tumor cells
In this study, the prophylactic effect of the main lectin present in Aloe vera leaf pulp extract (Aloctin I) was assayed against Ehrlich ascites tumours in mice. The lectin administered prophylactically before tumour implantation regressed tumour size, however, this activity was less potent than that of the A. vera leaf pulp extract previously shown in our laboratory. Accordingly, serum sialic acid and tumour necrosis factor alpha (TNF α ) levels, chosen as tumour markers, were decreased significantly by the prophylactic administration of the lectin. The increase in spleen and thymus weights in the group given only Aloctin I, could be explained by the immunomodulatory and mitogenic effects of lectins. These findings, along with lymphoid hyperplasia observed in spleen and thymus, suggest that the tumour preventive effect of Aloctin I could be due to its immunomodulatory activity. Copyright © 2007 John Wiley & Sons, Ltd.