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Hypoglycemic effects of Ganoderma applanatum and Collybia confluens exo‐polymers in streptozotocin‐induced diabetic rats
Author(s) -
Yang ByungKeun,
Jung YuSun,
Song ChiHyun
Publication year - 2007
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2214
Subject(s) - streptozotocin , aspartate transaminase , alanine transaminase , triglyceride , chemistry , plasma glucose , diabetes mellitus , traditional medicine , oral administration , pharmacology , endocrinology , medicine , cholesterol , biochemistry , enzyme , biology , alkaline phosphatase
The hypoglycemic effects of Ganoderma applanatum exo‐polymer (GAE) and Collybia confluens exo‐polymer (CCE) produced by submerged mycelial cultures in streptozotocin (STZ)‐induced diabetic rats were investigated. Hypoglycemic effects were achieved in both the GAE‐ and CCE‐treated groups by administration at a level of 100 mg/kg body weight (BW) daily for 3 weeks. The administration of GAE and CCE substantially reduced the plasma glucose levels by as much as 22.0% and 25.9%, respectively, when compared with the control group. The GAE and CCE also lowered the plasma total cholesterol and triglyceride levels by 20.3% and 22.5%, and by 22.7% and 25.5%, respectively. Furthermore, the activity of alanine transaminase (ALT) and aspartate transaminase (AST) was decreased by 23.2% and 20.7% in the GAE‐treated group, and it was also reduced by 28.7% and 23.6% in the CCE‐treated group. The results strongly demonstrate the potential of GAE and CCE in combating diabetes in experimental animals. Copyright © 2007 John Wiley & Sons, Ltd.