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Thymoquinone decreases AGE‐induced NF‐ κ B activation in proximal tubular epithelial cells
Author(s) -
Sayed Ahmed Amir Radwan,
Morcos Michael
Publication year - 2007
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2177
Subject(s) - thymoquinone , nf κb , microbiology and biotechnology , chemistry , medicine , apoptosis , pharmacology , biology , biochemistry , antioxidant
The inhibitory effects of thymoquinone (TQ) on activation of the redox‐sensitive transcription factor nuclear factor kappa B (NF‐ κ B) and interleukin‐6 (IL‐6) were studied in vitro . Human proximal tubular epithelial cells (pTECs) were cultivated and stimulated with advanced glycation end products (AGEs) and the effects of TQ were studied. A significant reduction of AGE‐induced NF‐ κ B‐activation and Il‐6 expression was observed. This points to potential antioxidative qualities of TQ. Copyright © 2007 John Wiley & Sons, Ltd.