Thymoquinone decreases AGE‐induced NF‐ κ B activation in proximal tubular epithelial cells | Zendy

Sayed Ahmed Amir Radwan | Zendy; Morcos Michael | Zendy

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Thymoquinone decreases AGE‐induced NF‐ κ B activation in proximal tubular epithelial cells

Author(s) -

Sayed Ahmed Amir Radwan,

Morcos Michael

Publication year - 2007

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.2177

Subject(s) - thymoquinone , nf κb , microbiology and biotechnology , chemistry , medicine , apoptosis , pharmacology , biology , biochemistry , antioxidant

The inhibitory effects of thymoquinone (TQ) on activation of the redox‐sensitive transcription factor nuclear factor kappa B (NF‐ κ B) and interleukin‐6 (IL‐6) were studied in vitro . Human proximal tubular epithelial cells (pTECs) were cultivated and stimulated with advanced glycation end products (AGEs) and the effects of TQ were studied. A significant reduction of AGE‐induced NF‐ κ B‐activation and Il‐6 expression was observed. This points to potential antioxidative qualities of TQ. Copyright © 2007 John Wiley & Sons, Ltd.

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