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Effect of the aqueous extract of Syzygium cumini on carbon tetrachloride‐induced hepatotoxicity in rats
Author(s) -
Moresco Rafael Noal,
Sperotto Rita Leal,
Bernardi Anie Schiavo,
Cardoso Ricardo França,
Gomes Patrícia
Publication year - 2007
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2158
Subject(s) - carbon tetrachloride , syzygium , alanine aminotransferase , traditional medicine , chemistry , aqueous solution , pharmacology , medicine , organic chemistry
The aim of this study was to evaluate the effect of the aqueous Syzygium cumini leaf extract, given either as a single dose or by 7 days of pretreatment, on hepatotoxicity induced by carbon tetrachloride in rats. Blood samples obtained after treatments were measured for aspartate aminotransferase (AST) and alanine aminotransferase (ALT). A significant increase in the AST and ALT activities occurred after carbon tetrachloride administration alone, which was significantly lowered by preadministration with the aqueous extract of Syzygium cumini , but not by a single dose. This suggests that the extract may be useful for liver protection but needs to be given over a significant period and prior to liver injury. Copyright © 2007 John Wiley & Sons, Ltd.