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Effect of essential oils and isolated compounds from Pimpinella species on NF‐ κ B: a target for antiinflammatory therapy
Author(s) -
Tabanca Nurhayat,
Ma Guoyi,
Pasco David S.,
Bedir Erdal,
Kirimer Nese,
Baser K. Husnu Can,
Khan Ikhlas A.,
Khan Shabana I.
Publication year - 2007
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2154
Subject(s) - nf κb , chemistry , pharmacology , transcription (linguistics) , cytotoxic t cell , pharmacognosy , traditional medicine , biological activity , transcription factor , stereochemistry , biology , biochemistry , in vitro , apoptosis , medicine , gene , linguistics , philosophy
Pimpinella essential oils and isolated compounds were screened for their inhibitory activity against NF‐ κ B mediated transcription in SW1353 cells. Twelve oils were effective in inhibiting NF‐ κ B mediated transcription. Especially the roots of P. corymbosa , P. tragium and P. rhodanta showed potent activities with IC 50 values of 2, 3 and 6 µg/mL, respectively. Five pure compounds, 7 (4‐(2‐propenyl)phenylangelate), 12 (4‐(3‐methyloxiranyl)phenyltiglate), 17 (4‐methoxy‐2‐(3‐methyloxiranyl)phenyl isobutyrate), 18 (4‐methoxy‐2‐(3‐methyloxiranyl)phenylangelate) and 21 (epoxy pseudoisoeugenol‐2‐methylbutyrate) inhibited NF‐ κ B mediated transcription with IC 50 values of 5.5, 1.2, 0.01, 3.6 and 11 µg/mL, respectively. None of the compounds were cytotoxic to mammalian cells. These findings add significant information to the pharmacological activity of Pimpinella species and their beneficial effects and use in disease prevention especially those related to inflammation. Copyright © 2007 John Wiley & Sons, Ltd.