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Anticancer activity of limonoid from Khaya senegalensis
Author(s) -
Zhang Huaping,
Wang Xi,
Chen Feng,
Androulakis Xiao M.,
Wargovich Michael J.
Publication year - 2007
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2148
Subject(s) - limonoid , meliaceae , khaya , dept , stereochemistry , chemistry , two dimensional nuclear magnetic resonance spectroscopy , traditional medicine , chemical structure , organic chemistry , medicine
Abstract Two limonoids were isolated from the methanol extract of Khaya senegalensis (Meliaceae), and their structures were identified as 3 α ,7 α ‐dideacetylkhivorin (1) and 1‐ O ‐acetylkhayanolide B (2) on the basis of MS and NMR spectral data. Complete assignments of 1 H and 13 C chemical shifts for compounds 1 and 2 were achieved by means of 1D and 2D NMR including DEPT, 1 H‐ 1 H COSY, HMQC, HMBC experiments. Compound 1 showed significant growth inhibitory activities against MCF‐7, SiHa and Caco‐2 cells with IC 50 values in the range of 0.07–0.14 µ m (35–69 ppm) while compound 2 did not. Copyright © 2007 John Wiley & Sons, Ltd.