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Ameliorative effects of pycnogenol ® on carbon tetrachloride‐induced hepatic oxidative damage in rats
Author(s) -
Ahn TaiHwan,
Yang YoungSu,
Lee JongChan,
Moon ChangJong,
Kim SungHo,
Jun Woojin,
Park SeungChun,
Kim JongChoon
Publication year - 2007
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2146
Subject(s) - malondialdehyde , carbon tetrachloride , superoxide dismutase , oxidative stress , chemistry , catalase , glutathione , antioxidant , pharmacology , biochemistry , medicine , enzyme , organic chemistry
This study evaluated the putative antioxidant activity of Pycnogenol ® (PYC) against CCl 4 ‐induced hepatic oxidative damage in Sprague‐Dawley rats. A single oral dose of CCl 4 (1.25 mL/kg) produced significantly increased levels of serum aminotransferase (AST) and alanine aminotransferase (ALT) activities. In addition, increased malondialdehyde (MDA) concentration, reduced glutathione (GSH) content, and decreased catalase, superoxide dismutase (SOD) and glutathione‐S‐transferase (GST) activities were observed in the hepatic tissues. However, concomitant administration with PYC (10 or 20 mg/kg) significantly improved CCl 4 ‐induced hepatic injury, as evidenced by the decline of serum AST and ALT activities in a dose dependent manner. Moreover, PYC reduced MDA concentration and increased GSH levels and catalase, SOD and GST activities in hepatic tissues, indicating that concomitant administration with PYC efficiently prevent the CCl 4 ‐induced oxidative damage in rats. The free radical scavenging assay showed that PYC has a dose‐dependent scavenging activity against 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) free radicals. These results indicate that PYC has an antioxidant effect against CCl 4 ‐induced hepatic oxidative damage and is useful as a hepatoprotective agent against various liver diseases induced by oxidative stress. Copyright © 2007 John Wiley & Sons, Ltd.