Identification and properties of 2,5‐Dihydroxy‐4,3′‐di( β ‐ d ‐glucopyranosyloxy)‐ trans ‐stilbene from  Morus bombycis  Koidzumi roots | Zendy

Jin YingShan | Zendy; Kim MinKyeong | Zendy; Heo SeongII | Zendy; Han Woong | Zendy; Wang MyeongHyeon | Zendy

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Identification and properties of 2,5‐Dihydroxy‐4,3′‐di( β ‐ d ‐glucopyranosyloxy)‐ trans ‐stilbene from Morus bombycis Koidzumi roots

Author(s) -

Jin YingShan,

Kim MinKyeong,

Heo SeongII,

Han Woong,

Wang MyeongHyeon

Publication year - 2007

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.2121

Subject(s) - phytotherapy , chemistry , stereochemistry , pharmacology , traditional medicine , medicine , pathology , alternative medicine

2,5‐Dihydroxy‐4,3′‐di( β ‐ d ‐glucopyranosyloxy)‐ trans ‐stilbene was identified from Morus bombycis Koidzumi roots. The 2,5‐dihydroxy‐4,3′‐di( β ‐ d ‐glucopyranosyloxy)‐ trans ‐stilbene at a dose of 400–600 mg/kg had hepatoprotective activity comparable to the standard agent, silymarin. The biochemical assays were confirmed by histological observations showing that the 2,5‐dihydroxy‐4,3′‐di( β ‐ d ‐glucopyranosyloxy)‐ trans ‐stilbene from Morus bombycis Koidzumi roots decreased cell ballooning in response to CCl 4 treatment. These results demonstrate that the 2,5‐dihydroxy‐4,3′‐di( β ‐ d ‐glucopyranosyloxy)‐ trans ‐stilbene component has a liver protective action against CCl 4 ‐induced hepatotoxicity. Copyright © 2007 John Wiley & Sons, Ltd.

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