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Identification and properties of 2,5‐Dihydroxy‐4,3′‐di( β ‐ d ‐glucopyranosyloxy)‐ trans ‐stilbene from Morus bombycis Koidzumi roots
Author(s) -
Jin YingShan,
Kim MinKyeong,
Heo SeongII,
Han Woong,
Wang MyeongHyeon
Publication year - 2007
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2121
Subject(s) - phytotherapy , chemistry , stereochemistry , pharmacology , traditional medicine , medicine , pathology , alternative medicine
2,5‐Dihydroxy‐4,3′‐di( β ‐ d ‐glucopyranosyloxy)‐ trans ‐stilbene was identified from Morus bombycis Koidzumi roots. The 2,5‐dihydroxy‐4,3′‐di( β ‐ d ‐glucopyranosyloxy)‐ trans ‐stilbene at a dose of 400–600 mg/kg had hepatoprotective activity comparable to the standard agent, silymarin. The biochemical assays were confirmed by histological observations showing that the 2,5‐dihydroxy‐4,3′‐di( β ‐ d ‐glucopyranosyloxy)‐ trans ‐stilbene from Morus bombycis Koidzumi roots decreased cell ballooning in response to CCl 4 treatment. These results demonstrate that the 2,5‐dihydroxy‐4,3′‐di( β ‐ d ‐glucopyranosyloxy)‐ trans ‐stilbene component has a liver protective action against CCl 4 ‐induced hepatotoxicity. Copyright © 2007 John Wiley & Sons, Ltd.