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Potent in vitro cytotoxic and antioxidant activity of Careya arborea bark extracts
Author(s) -
Senthilkumar Natesan,
Badami Shrishailappa,
Cherian Manju Mary,
Hariharapura Raghu Chandrasekar
Publication year - 2007
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2118
Subject(s) - hela , antioxidant , traditional medicine , cytotoxicity , ethyl acetate , chloroform , in vitro , vero cell , pharmacognosy , bark (sound) , chemistry , cytotoxic t cell , phenol , phenols , cell culture , pharmacology , biology , biological activity , biochemistry , medicine , organic chemistry , ecology , genetics
Careya arborea is used in traditional medicine for the treatment of tumors and other ailments. The successive chloroform and ethyl acetate extracts and crude 50% methanol extract exhibited potent cytotoxicity against cancerous RD, HEp‐2 and HeLa cell lines. They were found to be safe against the normal Vero cell line. The methanol and aqueous extracts possessed strong antioxidant activity against many oxidants in the in vitro antioxidant screening. The total phenol content of these extracts was found to be high. The results suggest strong cytotoxic and antioxidant properties and support the ethnomedical claims for the plant. Copyright © 2007 John Wiley & Sons, Ltd.