Premium
Wound healing activity of root extracts of Berberis lyceum royle in rats
Author(s) -
Asif A.,
Kakub G.,
Mehmood S.,
Khunum R.,
Gulfraz M.
Publication year - 2007
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2110
Subject(s) - hydroxyproline , wound healing , granulation tissue , traditional medicine , granulation , berberis , aqueous extract , breaking strength , methanol , medicine , chemistry , surgery , biochemistry , materials science , composite material , organic chemistry
The wound healing activities of the aqueous and methanol extracts of the root of Berberis lyceum were assessed using incision, excision and dead wound space models of wound repair in rats. After application of both extracts it was observed that the area of epithelialization increased, followed by an increase in wound contraction, skin breaking strength, tissue granulation, dry weight and hydroxyproline content. Histopathological studies of the granulation tissue also indicated that there was an increase in collagen formation in those rats treated with the methanol extract, compared with the control group animals. The methanol extract was more effective than the aqueous extract, but both showed significant results compared with the control. Copyright © 2007 John Wiley & Sons, Ltd.