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Ursolic acid: a potent Inhibitor of superoxides produced in the cellular system
Author(s) -
Ali Muhammad S.,
Ibrahim Syed A.,
Jalil Saima,
Choudhary Muhammad I.
Publication year - 2007
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2108
Subject(s) - ursolic acid , superoxide , xanthine oxidase , chemistry , xanthine , biochemistry , respiratory burst , pharmacology , traditional medicine , biology , medicine , enzyme , chromatography
Triterpenoids of ursane class: ursolic acid, ilelatifol D, corosolic acid and euscaphic acid were isolated for the first time from Leonurus cardiaca , a member of the family Lamiaceae. The isolated compounds were tested for their cell‐based antiinflammatory potential by suppressing respiratory burst activity and superoxide scavenging property by using xanthine/xanthine oxidase system to produce superoxides in the cell‐free system. Ursolic acid was found to be an excellent inhibitor for the superoxides produced in the cellular system, while the same was inactive in the superoxide scavenging activity in cell‐free system. Copyright © 2007 John Wiley & Sons, Ltd.