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Evaluation of the growth inhibitory activities of triphala against common bacterial isolates from HIV infected patients
Author(s) -
Srikumar R.,
Parthasarathy N. Jeya,
Shankar E. M.,
Manikandan S.,
Vijayakumar R.,
Thangaraj R.,
Vijayananth K.,
Sheeladevi R.,
Rao Usha Anand
Publication year - 2007
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2105
Subject(s) - terminalia chebula , traditional medicine , phytochemical , microbiology and biotechnology , salmonella typhi , minimum inhibitory concentration , officinalis , antibacterial activity , enterococcus faecalis , biology , medicine , staphylococcus aureus , antibiotics , escherichia coli , bacteria , biochemistry , genetics , gene
The isolation of microbial agents less susceptible to regular antibiotics and the rising trend in the recovery rates of resistant bacteria highlights the need for newer alternative principles. Triphala has been used in traditional medicine practice against certain diseases such as jaundice, fever, cough, eye diseases etc. In the present study phytochemical (phenolic, flavonoid and carotenoid) and antibacterial activities of aqueous and ethanol extracts of Triphala and its individual components ( Terminalia chebula , Terminalia belerica and Emblica officinalis ) were tested against certain bacterial isolates ( Pseudomonas aeruginosa , Klebsiella pneumoniae , Shigella sonnei , S. flexneri , Staphylococcus aureus , Vibrio cholerae , Salmonella paratyphi‐B , Escherichia coli , Enterococcus faecalis , Salmonella typhi ) obtained from HIV infected patients using Kirby‐Bauer's disk diffusion and minimum inhibitory concentration (MIC) methods. T. chebula was found to possess high phytochemical content followed by T. belerica and E. officinalis in both aqueous and ethanol extracts. Further, most of the bacterial isolates were inhibited by the ethanol and aqueous extracts of T. chebula followed by T. belerica and E. officinalis by both disk diffusion and MIC methods. The present study revealed that both individual and combined aqueous and ethanol extracts of Triphala have antibacterial activity against the bacterial isolates tested. Copyright © 2007 John Wiley & Sons, Ltd.