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Modulation of P‐glycoprotein activity by acridones and coumarins from Citrus sinensis
Author(s) -
Bayet C.,
Fazio C.,
Darbour N.,
Berger O.,
Raad I.,
Chaboud A.,
Dumontet C.,
Guilet D.
Publication year - 2007
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2081
Subject(s) - limonin , rutaceae , terpenoid , pharmacognosy , citrus × sinensis , p glycoprotein , chemistry , glycoprotein , traditional medicine , biology , biological activity , in vitro , biochemistry , botany , orange (colour) , medicine , multiple drug resistance , food science , antibiotics
Bioguided fractionation of the roots of Citrus sinensis (Rutaceae) led to the isolation and identification of five coumarins, namely, clausarin, suberosin, poncitrin, xanthyletin and thamnosmonin, seven acridones, namely, acrimarine B, 2‐methoxycitpressine I, citpressine I, buntanine, acrimarine E, honyumine and acrimarine C, and one terpenoid, namely, limonin. Among these compounds, clausarin, 2‐methoxycitpressine I and acrimarine E inhibited P‐glycoprotein‐mediated drug efflux in K562/R7 human leukemic cells over‐expressing P‐glycoprotein. Copyright © 2007 John Wiley & Sons, Ltd.