In vitro  activities of  Citrus medica  L. cv. Diamante (Diamante citron) relevant to treatment of diabetes and Alzheimer's disease | Zendy

Conforti Filomena | Zendy; Statti Giancarlo Antonio | Zendy; Tundis Rosa | Zendy; Loizzo Monica Rosa | Zendy; Menichini Francesco | Zendy

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In vitro activities of Citrus medica L. cv. Diamante (Diamante citron) relevant to treatment of diabetes and Alzheimer's disease

Author(s) -

Conforti Filomena,

Statti Giancarlo Antonio,

Tundis Rosa,

Loizzo Monica Rosa,

Menichini Francesco

Publication year - 2007

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.2077

Subject(s) - rutaceae , antioxidant , dpph , traditional medicine , limonene , chemistry , pharmacology , medicine , food science , biochemistry , essential oil , biology , botany

The present study showed for the first time the in vitro properties (antioxidant, hypoglycaemic and anticholinesterase) of Citrus medica L. cv. Diamante which belongs to the Rutaceae family. The n ‐hexane extract of Diamante citron peel is characterized by the presence of monoterpenes and sesquiterpenes. The most abundant constituents were two monoterpenes: limonene and γ ‐terpinene. The extract showed significant antioxidant activity that was carried out using different assays (DPPH test, β ‐carotene bleaching test and bovine brain peroxidation assay). Oxidative damage, caused by the action of free radicals, may initiate and promote the progression of a number of chronic diseases, including diabetes and Alzheimer's disease. Diamante citron peel extract showed hypoglycaemic activity and an anticholinesterase effect. Copyright © 2007 John Wiley & Sons, Ltd.

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