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Pterocarpus santalinus: an In Vitro study on its anti‐ Helicobacter pylori effect
Author(s) -
Narayan Shoba,
Veeraraghavan Mani,
Devi C. S. Shyamala
Publication year - 2007
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2047
Subject(s) - helicobacter pylori , lactate dehydrogenase , in vitro , urease , traditional medicine , spirillaceae , lipid peroxidation , microbiology and biotechnology , biology , chemistry , biochemistry , medicine , enzyme , gastritis , genetics
The anti‐ H. pylori activity of Pterocarpus santalinus (PS), a traditional herb, has been assessed and compared with that of bismuth subcitrate, through in vitro studies employing rat gastric epithelial cell cultures and H. pylori isolates from gastric mucosal biopsy patients. The MIC of PS was found to be 20 µg/mL. H. pylori was co‐cultivated with rat gastric epithelial cells in the presence/absence of PS at its MIC. A reduction in the activity of urease, a normal appearance of the epithelial cells on electron microscopic examination, a decrease in lipid peroxidation and lactate dehydrogenase suggests the possible anti‐ H. pylori activity of PS. Copyright © 2006 John Wiley & Sons, Ltd.