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Antiproliferative Effect of Furanocoumarins from the Root of Angelica dahurica on Cultured Human Tumor Cell Lines
Author(s) -
Kim YoungKyoon,
Kim Young Sup,
Ryu Shi Yong
Publication year - 2007
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2043
Subject(s) - imperatorin , pharmacognosy , in vitro , traditional medicine , pharmacology , biological activity , fractionation , cell culture , cell growth , chemistry , furanocoumarin , bioassay , biology , biochemistry , chromatography , high performance liquid chromatography , medicine , genetics
A bioassay‐guided fractionation of the root extract of Angelica dahurica (Umbelliferae) led to the isolation of six furanocoumarins as active ingredients responsible for the antitumoral property. The hexane soluble part of the extract demonstrated a signicant inhibition on the proliferation of cultured human tumor cells such as A549 (non small cell lung), SK‐OV‐3 (ovary), SK‐MEL‐2 (melanoma), XF498 (central nervous system) and HCT‐15 (colon) in vitro , whereas the remaining water soluble part exhibited poor inhibition. Intensive investigation of the hexane soluble part of the extract yielded six furanocoumarins, i.e. isoimperatorin, cnidicin, imperatorin, oxypeucedanin, byakangelicol, oxypeucedanin hydrate, all of which exhibited a signicant inhibition on cell proliferation in a dose‐dependent manner. Copyright © 2006 John Wiley & Sons, Ltd.