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Antiinflammatory activity of ethanol extracts of Hypericum perforatum L., H. barbatum Jacq., H. hirsutum L., H. richeri Vill. and H. androsaemum L. in rats
Author(s) -
Šavikin Katarina,
Dobrić Silva,
Tadić Vanja,
Zdunić Gordana
Publication year - 2007
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2041
Subject(s) - hypericum perforatum , hypericin , traditional medicine , ethanol , carrageenan , biology , pharmacology , chemistry , medicine , biochemistry
Ethanol extracts of the aerial parts of six Hypericum species, H. barbatum , H. androsaemum , H. richerii , H. hirsutum , H. perforatum and H. perforatum cultivated on mountain Tara were tested for antiinflammatory activity in comparison with indomethacin (IND) using the carrageenan‐induced rat paw edema test. It was found that all examined extracts produced antiinflammatory activity, particularly those from H. hirsutum , and both wild and cultivated H. perforatum . A dose‐dependent antiinflammatory effect was especially pronounced in extracts showing some lower antiinflammatory activity. There was no correlation between the amount of hypericin in the extracts and their antiinflammatory activity. Copyright © 2006 John Wiley & Sons, Ltd.