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Potential cytotoxic activity of some Brazilian seaweeds on human melanoma cells
Author(s) -
Rocha Fabíola Dutra,
Soares Angélica Ribeiro,
Houghton Peter John,
Pereira Renato Crespo,
Kaplan Maria Auxiliadora Coelho,
Teixeira Valéria Laneuville
Publication year - 2007
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2038
Subject(s) - acetone , cytotoxicity , cytotoxic t cell , chloroform , dichloromethane , cell culture , in vitro , pharmacognosy , chemistry , traditional medicine , melanoma , biochemistry , biological activity , biology , chromatography , medicine , cancer research , solvent , genetics
In vitro screening of the crude extracts of some Brazilian coastal seaweeds for cytotoxic activity against a cultured human melanoma cancer cell line using the sulphorhodamine B assay was performed. The crude dichloromethane:chloroform extract of Stypopodium zonale showed good cytotoxic activity against the C32 cell line. The crude acetone extract and aqueous phase of Lobophora variegata did not show any activity, but semi‐purified fractions XAD LOB I and II could inhibit the growth of melanoma cells. The crude acetone extract of Caulerpa racemosa showed some cytotoxicity, but caulerpin isolated from this extract did not show any such activity. The crude acetone extract of Spatoglossum schroederi was not able to inhibit the growth of C32 melanoma cells. Copyright © 2006 John Wiley & Sons, Ltd.