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Kamikihi‐to, a Kampo medicine, Ameliorates impairment of spatial memory in rats
Author(s) -
Egashira Nobuaki,
Manome Naomi,
Kurauchi Kouji,
Matsumoto Yoshiaki,
Iwasaki Katsunori,
Mishima Kenichi,
Shoyama Yukihiro,
Fujiwara Michihiro
Publication year - 2007
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2034
Subject(s) - memory impairment , kampo , agonist , pharmacology , muscarinic acetylcholine receptor , karush–kuhn–tucker conditions , antagonist , muscarinic antagonist , medicine , oxotremorine , receptor , psychiatry , mathematics , cognition , mathematical optimization , alternative medicine , pathology
The present study investigated the effects of Kamikihi‐to (KKT), a Kampo medicine, on impairment of spatial memory in rats using an eight‐arm radial maze task. Scopolamine (0.5 mg/kg, i.p.), a non‐selective muscarinic receptor antagonist, and Δ 9 ‐tetrahydrocannabinol (THC; 6 mg/kg, i.p.), a principal psychoactive component of marihuana, each markedly impaired the spatial memory. KKT (1 and 3 mg/kg, p.o.) significantly improved the scopolamine‐induced impairment of spatial memory. KKT (30 mg/kg, p.o.) also improved significantly the THC‐induced impairment of spatial memory. Moreover, KKT (3 and 30 mg/kg, p.o.) enhanced tremors induced by oxotremorine, a muscarinic M 1 receptor agonist. Taken together these findings suggest that KKT is a useful drug for treating memory deficits. Copyright © 2006 John Wiley & Sons, Ltd.