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Immunostimulating effects of the polyphenol‐rich fraction of sugar cane ( Saccharum officinarum L.) extract in chickens
Author(s) -
Hikosaka Kenji,
ElAbasy Moshira,
Koyama Yukari,
Motobu Maki,
Koge Kenji,
Isobe Takashi,
Kang ChungBoo,
Hayashidani Hideki,
Onodera Takashi,
Wang PiChao,
Matsumura Masatoshi,
Hirota Yoshikazu
Publication year - 2007
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2033
Subject(s) - splenocyte , saline , broiler , cane , saccharum officinarum , oral administration , globulin , biology , sugar , medicine , pharmacology , immunology , antibody , zoology , endocrinology , food science , botany
The phagocytic activity of peripheral blood leukocytes (PBL) in chickens orally administered sugar cane extracts (SCE) or polyphenol‐rich fraction (PRF) of SCE (500 mg/kg/day) for 3 consecutive days increased significantly, when compared with that of saline‐administered control chickens. Chickens orally administered SCE or PRF (500 mg/kg/day) for 3 consecutive days showed significantly higher antibody responses against sheep red blood cells and Brucella abortus than control chickens. In addition, oral administration of SCE or PRF also resulted in a significant increase in the number of IgM‐ and IgG‐plaque forming cell responses of PBL, intestinal leukocytes and splenocytes, when compared with those of control chickens. Furthermore, delayed type hypersensitivity responses to human γ globulin significantly increased in chickens orally administered SCE or PRF, compared with those of control chickens when evaluated on the basis of net increased wattle thickness at 24, 48 and 72 h after challenge. These results suggest that PRF of SCE has an immunostimulating effect in chickens. Copyright © 2006 John Wiley & Sons, Ltd.