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Pycnogenol increases the probability of the contraction state in chick embryonic cardiomyocytes, indicating inotropic effects
Author(s) -
Hasegawa Noboru,
Kinoshita Hiromi,
Mochizuki Miyako
Publication year - 2007
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2022
Subject(s) - contraction (grammar) , inotrope , propranolol , antagonist , medicine , stimulation , endocrinology , muscle contraction , chemistry , receptor , biology
The influence of pycnogenol on the probability of contraction was studied in chick cardiomyocytes. Ventricles from 9–11 day chicken embryos were cultured. After 10–11 days in culture, stable spontaneous contractions were recorded and the contraction kinetics analysed. Isoproterenol and pycnogenol increased the probability of the contraction state. After pretreatment with the β ‐receptor antagonist, propranolol reduced the isoproterenol‐ and pycnogenol‐increased probability of contraction state. These data suggested that pycnogenol has inotropic effects via stimulation of β ‐receptor mediated activity. Copyright © 2006 John Wiley & Sons, Ltd.