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Anethole, a potential antimicrobial synergist, converts a fungistatic dodecanol to a fungicidal agent
Author(s) -
Fujita Kenichi,
Fujita Tomoko,
Kubo Isao
Publication year - 2007
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.2016
Subject(s) - anethole , dodecanol , viability assay , candida albicans , chemistry , fungicide , antimicrobial , antifungal , yeast , traditional medicine , biology , food science , microbiology and biotechnology , biochemistry , cell , botany , organic chemistry , medicine , essential oil
Anethole shows synergistic effects on the antifungal activities of phytochemicals including polygodial and (2 E )‐undecenal against Saccharomyces cerevisiae and Candida albicans . It was found that a fungistatic dodecanol combined with a sublethal amount of anethole showed a fungicidal activity against S. cerevisiae . The MIC of dodecanol quickly reduced cell viability, but the cell viability recovered shortly after and then finally became no longer different from the control, indicating that the effect of dodecanol on this yeast was classified as sublethal damage. On the other hand, anethole completely restricted the recovery of cell viability. Therefore the expression of the synergistic effect was probably due to a blockade of the recovery process from dodecanol‐induced stress. Copyright © 2006 John Wiley & Sons, Ltd.