Antiplasmodial activity of  Homalium letestui | Zendy

Okokon Jude E. | Zendy; Ita Basil | Zendy; Udokpoh Aniekan E. | Zendy

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Antiplasmodial activity of Homalium letestui

Author(s) -

Okokon Jude E.,

Ita Basil,

Udokpoh Aniekan E.

Publication year - 2006

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.1983

Subject(s) - plasmodium berghei , malaria , chloroquine , traditional medicine , pharmacognosy , pharmacology , in vivo , medicine , biology , biological activity , immunology , in vitro , microbiology and biotechnology , biochemistry

The in vivo antiplasmodial activity of the ethanol root extract of Homalium letestui used as a malaria remedy in Southern Nigeria was evaluated in Plasmodium berghei berghei infected mice. Homalium letestui root extract (500–1000 mg/kg/day) exhibited significant ( p < 0.05) blood schizontocidal activities both in a 4‐day early infection test and in an established infection with a considerable mean survival time comparable to that of the standard drug, chloroquine, 5 mg/kg/day. The root extract possesses significant ( p < 0.05) antiplasmodial activity, which can be exploited in malaria therapy. Copyright © 2006 John Wiley & Sons, Ltd.

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