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In Vitro evaluation of effects of two ghanaian plants relevant to wound healing
Author(s) -
Mensah Abraham Y.,
Houghton Peter J.,
Dickson Rita A.,
Fleischer T. C.,
Heinrich M.,
Bremner P.
Publication year - 2006
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1978
Subject(s) - traditional medicine , antimicrobial , antioxidant , bark (sound) , hydrogen peroxide , lipid peroxidation , wound healing , phytotherapy , pharmacognosy , chemistry , antiseptic , in vitro , pharmacology , biology , medicine , microbiology and biotechnology , biological activity , biochemistry , surgery , ecology , alternative medicine , pathology , organic chemistry
Commelina diffusa and Spathodea campanulata are used as wound‐healing agents in Ashanti traditional medicine in Ghana. The methanol extracts of Commelina diffusa herb and Spathodea campanulata bark showed some level of antimicrobial activity with C. diffusa exhibiting selective antifungal activity against Trichophyton species. The extracts reduced the peroxidation of bovine brain extract with an IC 50 value of 1.39 mg/mL and 0.24 mg/mL, respectively. In addition the extracts also exhibited significant antioxidant activity by protecting MRC‐5 cells from hydrogen peroxide induced oxidant injury at concentrations between 1 µg/mL and 10 µg/mL. The extracts showed no inhibition of NF‐ κ B at 100 µg/mL. The antioxidant activities and antimicrobial activities suggest that the use of the plants in wound healing may be based on antioxidant and antiseptic effects of its constituents. Copyright © 2006 John Wiley & Sons, Ltd.