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In vitro antiviral activities of Chinese medicinal herbs against duck hepatitis B virus
Author(s) -
Leung K. T.,
Chiu Lawrence C. M.,
Lam W. S.,
Li Yaolan,
Sun Samuel S. M.,
Ooi Vincent E. C.
Publication year - 2006
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1969
Subject(s) - duck hepatitis b virus , traditional medicine , biology , virology , in vitro , cytotoxicity , virus , medicinal herbs , hepatocyte , hepatitis b virus , pharmacognosy , medicine , hepadnaviridae , biological activity , biochemistry
Fifty‐six different Chinese medicinal herbs from 29 families were evaluated for their antiviral activities against duck hepatitis B virus (DHBV) in vitro . The DHBV DNA level in primary duck hepatocyte cultures was monitored by dot blot hybridization and the cytotoxicity was evaluated by MTT assay. Anti‐DHBV activities were found more strongly in the aqueous extracts of Ardisia chinensis and Pithecellobium clypearia with selective indices of 2.6 and >2.7, respectively, which were comparable to that of 2′,3′‐dideoxycytidine. Further research on the isolation of the active antiviral phytochemicals from these herbs may provide alternative options for the treatment of chronic hepatitis B. Copyright © 2006 John Wiley & Sons, Ltd.