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Retracted : Effects of thymoquinone (volatile oil of black cumin) on rheumatoid arthritis in rat models
Author(s) -
Tekeoglu Ibrahim,
Dogan Ali,
Demiralp Levent
Publication year - 2006
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1964
Subject(s) - thymoquinone , nigella sativa , medicine , rheumatoid arthritis , arthritis , methotrexate , adjuvant , inflammation , pharmacology , traditional medicine , immunology , chemistry , biochemistry , antioxidant
Many studies have been carried out in recent years on the pharmacological effects of nigella sativa seeds that have uncovered their antiinflammatory and immunological effects. The objective of this study was to explore the antiinflammatory effects of thymoquinone on arthritis in rat models. Rats with arthritis induced by Freund's incomplete adjuvant were assigned into five groups: group 1: controls 0.9% NaCl ( n = 7); group 2: 2.5 mg/kg thymoquinone ( n = 7); group 3: 5 mg/kg thymoquinone ( n = 7); group 4: Bacilli Chalmette Guerin (BCG) 6 × 10 5 CFU ( n = 7); group 5: methotrexate 0.3 mg/kg ( n = 7). Signs of inflammation on the claw and radiological signs were searched for and TNF‐alpha and IL‐1beta were measured. The results of control and other groups were compared. As a result, thymoquinone, confirmed clinically and radiologically, suppressed adjuvant‐induced arthritis in rats. Copyright © 2006 John Wiley & Sons, Ltd.