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Retracted: Effect of Meso ‐dihydroguaiaretic acid from Machilus thunbergii Sieb et Zucc on MMP‐1 expression in heat shock‐induced cultured primary human fibroblasts
Author(s) -
Moon Hyungin,
Jung JaeChul
Publication year - 2006
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1941
Subject(s) - lauraceae , in vitro , matrix metalloproteinase , chemistry , heat stress , shock (circulatory) , traditional medicine , biochemistry , biology , botany , medicine , zoology
This article has been retracted. See retraction notice DOI: 10.1002/ptr.2151 Ethanol and aqueous extracts of Machilus thunbergii Sieb et Zucc (Lauraceae) used traditionally for the treatment of a variety of diseases were screened in vitro for MMP‐1 inhibitory actions. Meso ‐dihydroguaiaretic acid (MDGA) from the stem bark of M. thunbergii showed a significant inhibition of matrix metalloproteinase (MMP)‐1 in primary human fibroblasts by heat shock‐induced. This study investigated the effect of MDGA isolated from M. thunbergii on heat shock‐induced premature skin aging. MDGA reduced the expression of MMP‐1 at the protein level in a dose‐dependent manner in heat shock‐induced cultured primary human fibroblasts. Taken together, these results show that MDGA can prevent the harmful effects of heat (and/or IR) that lead to skin aging. Copyright © 2006 John Wiley & Sons, Ltd.