Inhibitory activity on HIV‐1 reverse transcriptase and integrase of a carmalol derivative from a brown Alga,  Ishige okamurae | Zendy

Ahn M.J. | Zendy; Yoon K.D. | Zendy; Kim C. Y. | Zendy; Kim J. H. | Zendy; Shin C.G. | Zendy; Kim J. | Zendy

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Inhibitory activity on HIV‐1 reverse transcriptase and integrase of a carmalol derivative from a brown Alga, Ishige okamurae

Author(s) -

Ahn M.J.,

Yoon K.D.,

Kim C. Y.,

Kim J. H.,

Shin C.G.,

Kim J.

Publication year - 2006

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.1939

Subject(s) - integrase , reverse transcriptase , enzyme , integrase inhibitor , inhibitory postsynaptic potential , pharmacognosy , biology , derivative (finance) , virology , human immunodeficiency virus (hiv) , biochemistry , chemistry , biological activity , rna , in vitro , antiretroviral therapy , viral load , gene , neuroscience , financial economics , economics

The bioassay‐directed isolation of a marine brown alga, Ishige okamurae , afforded a carmalol derivative, diphlorethohydroxycarmalol. This compound exhibited inhibitory effects on HIV‐1 reverse transcriptase and integrase with IC 50 values of 9.1 µ m and 25.2 µ m , respectively. However, diphlorethohydroxycarmalol did not show an inhibitory activity against HIV‐1 protease. Moreover, diphlorethohydroxycarmalol nonaacetate obtained by acetylation and fucosterol failed to show any inhibitory activity against these viral enzymes. Copyright © 2006 John Wiley & Sons, Ltd.

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