Premium
Inhibitory activity on HIV‐1 reverse transcriptase and integrase of a carmalol derivative from a brown Alga, Ishige okamurae
Author(s) -
Ahn M.J.,
Yoon K.D.,
Kim C. Y.,
Kim J. H.,
Shin C.G.,
Kim J.
Publication year - 2006
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1939
Subject(s) - integrase , reverse transcriptase , enzyme , integrase inhibitor , inhibitory postsynaptic potential , pharmacognosy , biology , derivative (finance) , virology , human immunodeficiency virus (hiv) , biochemistry , chemistry , biological activity , rna , in vitro , antiretroviral therapy , viral load , gene , neuroscience , financial economics , economics
The bioassay‐directed isolation of a marine brown alga, Ishige okamurae , afforded a carmalol derivative, diphlorethohydroxycarmalol. This compound exhibited inhibitory effects on HIV‐1 reverse transcriptase and integrase with IC 50 values of 9.1 µ m and 25.2 µ m , respectively. However, diphlorethohydroxycarmalol did not show an inhibitory activity against HIV‐1 protease. Moreover, diphlorethohydroxycarmalol nonaacetate obtained by acetylation and fucosterol failed to show any inhibitory activity against these viral enzymes. Copyright © 2006 John Wiley & Sons, Ltd.