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Effects of Papaver rhoeas extract on the acquisition and expression of morphine‐induced behavioral sensitization in mice
Author(s) -
Sahraei Hedayat,
FaghihMonzavi Zohreh,
Fatemi Sayedeh Maedeh,
PashaeiRad Shahrokh,
Salimi Seyed Hossein,
Kamalinejad Mohammad
Publication year - 2006
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1922
Subject(s) - sensitization , morphine , pharmacology , behavioral sensitization , ratón , intraperitoneal injection , medicine , chemistry , central nervous system , immunology , nucleus accumbens
In the present study, the effects of a water‐alcohol extract of Papaver rhoeas on the acquisition and expression of morphine‐induced behavioral sensitization in mice were investigated. The subcutaneous (s.c.) administration of morphine (50 mg/kg) induced locomotor activity in animals, whereas the drug did not show an effect at a dose of 5 mg/kg. On the other hand, intraperitoneal (i.p.) administration of the plant extract (25, 50 and 100 mg/kg) did not show any effect. The locomotor behavioral response was enhanced in mice pretreated with morphine (5 mg/kg, daily × 3 days) alone, indicating that sensitization had developed. Extract (25, 50 and 100 mg/kg, i.p.) administration, 30 min before each of the three daily doses of morphine decreased the development of sensitization. Moreover, intraperitoneal administration of the plant extract (25, 50 and 100 mg/kg) 30 min before the test reduced the expression of morphine‐induced behavioral sensitization. The results indicate that administration of the extract of Papaver rhoeas reduced the acquisition and expression of morphine‐induced behavioral sensitization in mice. Copyright © 2006 John Wiley & Sons, Ltd.