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Tumor cell‐selective antiproliferative effect of the extract from Morinda citrifolia fruits
Author(s) -
Arpornsuwan Teerakul,
Punja Tadsanee
Publication year - 2006
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1902
Subject(s) - cytotoxicity , baby hamster kidney cell , vero cell , cytotoxic t cell , mtt assay , toxicity , cell culture , traditional medicine , hamster , pharmacognosy , neuroblastoma , kidney , biology , pharmacology , cell , chemistry , microbiology and biotechnology , biological activity , in vitro , medicine , biochemistry , endocrinology , genetics , organic chemistry
The methanol extract from Morinda citrifolia fruits was tested for cytotoxicity activity on the MTT assay. The appearance of cytotoxic changes after exposure to the extract was in a concentration dependent manner. The median lethal concentrations (LC 50 ) of the extract in baby hamster kidney (BHK) cells, African green monkey kidney (Vero) cells and human laryngeal carcinoma (Hep2) cells were found to be 2.5, 3 and 5 mg/mL, respectively. A concentration of 0.1 mg/mL of crude extract exhibited cytotoxic activity against breast cancer (MCF7) and neuroblastoma (LAN5) cell lines at 29% and 36%, respectively. The same concentration of extract showed no toxicity to Vero and very little toxicity to BHK (6%) and Hep2 (13%) cells. Copyright © 2006 John Wiley & Sons, Ltd.