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Cytotoxicity in vitro of naphthazarin derivatives from Onosma arenaria
Author(s) -
Kundaković Tatjana,
Stanojković Tatjana,
Juranić Zorica,
Kovačević Nada
Publication year - 2006
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1899
Subject(s) - in vitro , cytotoxicity , biology , biochemistry
The cytotoxicity of naphthazarin derivatives isolated from the roots of Onosma arenaria on human cervix adenocarcinoma cells (HeLa) and leukaemia K562 cells, as well on non‐malignant peripheral blood mononuclear cells (PBMC) was studied. The results show that β ‐hydroxyisovalerylalkannin, acetylalkannin and the pigment fraction exhibited high cytotoxicity in vitro against the tested cell lines, as well the healthy PBMC before or after activation with phytohaemagglutinin. Copyright © 2006 John Wiley & Sons, Ltd.