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Fatty acids profile and antiinflammatory activity of Nonea setosa R. et S.
Author(s) -
Curini Massimo,
Epifano Francesco,
Genovese Salvatore,
Menghini Alessandro,
Altinier Gianmario,
Tubaro Aurelia,
Menghini Luigi
Publication year - 2006
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1886
Subject(s) - boraginaceae , croton , fractionation , pharmacognosy , croton oil , polyunsaturated fatty acid , chemistry , traditional medicine , bioassay , biology , biological activity , fatty acid , botany , chromatography , biochemistry , in vitro , inflammation , medicine , immunology , genetics
In order to verify the antiinflammatory properties of Nonea setosa R. et S. (Fam. Boraginaceae) and to identify the relevant active principles, aerial parts of this plant were extracted with increasing polarity solvents. The antiinflammatory activity was investigated by a bioassay‐oriented fractionation using the inhibition of the croton oil‐induced ear oedema in mice as an experimental model of inflammation. GC‐MS analysis of the most active fraction revealed the presence of high amounts of polyunsaturated fatty acids. Copyright © 2006 John Wiley & Sons, Ltd.