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Antiplatelet activity of aporphine and phenanthrenoid alkaloids from Aromadendron elegans blume
Author(s) -
Jantan Ibrahim,
Raweh Salwa M.,
Yasin Yusyila Harlina Mohd,
Murad Shahnaz
Publication year - 2006
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1885
Subject(s) - arachidonic acid , aporphine , platelet , in vitro , chemistry , platelet aggregation , stereochemistry , pharmacology , platelet aggregation inhibitor , pharmacognosy , whole blood , alkaloid , biochemistry , biological activity , biology , aspirin , enzyme , immunology
Six aporphine and one phenanthrenoid alkaloids isolated from Aromadendron elegans Blume were investigated for their ability to inhibit arachidonic acid (AA), collagen and ADP induced platelet aggregation in human whole blood. The antiplatelet activity of the compounds was measured in vitro by the Chrono Log whole blood aggregometer using an electrical impedance method. Of the compounds tested, (‐)‐N‐acetylnornuciferine, (‐)‐N‐acetylanonaine and 1‐(N‐acetyl‐N‐methylamino)ethyl‐3,4,6‐trimethoxy‐7‐hydroxyphenanthrene showed strong inhibition on platelet aggregation caused by all three inducers. (‐)‐N‐acetylanonaine was the most effective antiplatelet compound as it inhibited both arachidonic acid, collagen and ADP‐induced platelet aggregation with IC 50 values of 66.1, 95.1 and 80.6 µ m , respectively. Copyright © 2006 John Wiley & Sons, Ltd.