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Reactive radical scavenging and xanthine oxidase inhibition of proanthocyanidins from Carallia brachiata
Author(s) -
Phuwapraisirisan Preecha,
Sowanthip Preecha,
Miles D. Howard,
Tippyang Santi
Publication year - 2006
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1877
Subject(s) - xanthine oxidase , dpph , chemistry , antioxidant , proanthocyanidin , stereochemistry , hydroxyl radical , xanthine , scavenging , radical , benzoic acid , pharmacognosy , superoxide , bark (sound) , biochemistry , biological activity , enzyme , in vitro , polyphenol , biology , ecology
Antioxidant‐guided separation of Carallia brachiata bark led to a new A‐type trimeric proanthocyanidin named carallidin (1), along with mahuannin A (2) and p ‐hydroxy benzoic acid (3). The structure of 1 was fully characterized by interpretation of spectroscopic data and chemical means. Compounds 1 and 2 exhibited radical scavenging against DPPH (IC 50 102 and 182 µ m ) and superoxide radical (IC 50 1.47 and 9.74 µ m ). In addition, 1 and 2 also inhibited xanthine oxidase with IC 50 values of 12.9 and 16.0 µ m . Copyright © 2006 John Wiley & Sons, Ltd.