Reactive radical scavenging and xanthine oxidase inhibition of proanthocyanidins from  Carallia brachiata | Zendy

Phuwapraisirisan Preecha | Zendy; Sowanthip Preecha | Zendy; Miles D. Howard | Zendy; Tippyang Santi | Zendy

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Reactive radical scavenging and xanthine oxidase inhibition of proanthocyanidins from Carallia brachiata

Author(s) -

Phuwapraisirisan Preecha,

Sowanthip Preecha,

Miles D. Howard,

Tippyang Santi

Publication year - 2006

Publication title -

phytotherapy research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.019

H-Index - 129

eISSN - 1099-1573

pISSN - 0951-418X

DOI - 10.1002/ptr.1877

Subject(s) - xanthine oxidase , dpph , chemistry , antioxidant , proanthocyanidin , stereochemistry , hydroxyl radical , xanthine , scavenging , radical , benzoic acid , pharmacognosy , superoxide , bark (sound) , biochemistry , biological activity , enzyme , in vitro , polyphenol , biology , ecology

Antioxidant‐guided separation of Carallia brachiata bark led to a new A‐type trimeric proanthocyanidin named carallidin (1), along with mahuannin A (2) and p ‐hydroxy benzoic acid (3). The structure of 1 was fully characterized by interpretation of spectroscopic data and chemical means. Compounds 1 and 2 exhibited radical scavenging against DPPH (IC 50 102 and 182 µ m ) and superoxide radical (IC 50 1.47 and 9.74 µ m ). In addition, 1 and 2 also inhibited xanthine oxidase with IC 50 values of 12.9 and 16.0 µ m . Copyright © 2006 John Wiley & Sons, Ltd.

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