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Lipid lowering activity of hydrosoluble chitosan and association with Aloe vera L. and Brassica olearaceae L.
Author(s) -
Geremias R.,
Pedrosa R. C.,
Locatelli C.,
de Fávere V. T.,
CouryPedrosa R.,
Laranjeira M. C. M.
Publication year - 2006
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1854
Subject(s) - chitosan , aloe vera , pharmacognosy , traditional medicine , chemistry , biological activity , medicine , biochemistry , in vitro
The lipid lowering activity of chitosan associated with Aloe vera L. or hydrosoluble chitosan with Brassica olearaceae L. has been studied in rats. In this study, rats were submitted to different treatments with hydrosoluble chitosan alone (4% diet), hydrosoluble chitosan associated with Aloe vera L. or hydrosoluble chitosan with Brassica olearaceae L. (1:4, 4% diet) for 35 days, to identify the formula with the highest hypolipaemic potential. The results showed that all treatments reduced blood lipid levels but that hydrosoluble chitosan associated with Brassica olearaceae L. proved most efficient, because it decreased the levels of total cholesterol, LDL‐cholesterol, VLDL‐cholesterol and triglycerides in blood serum. The overall results suggest that the hydrosoluble chitosan/ Brassica olearaceae L. association is a therapeutic alternative for hyperlipidaemia, and in this way may contribute to the prevention of atherogenic processes. Copyright © 2006 John Wiley & Sons, Ltd.