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Suppression of T lymphocyte activity by lupeol isolated from Crataeva religiosa
Author(s) -
Bani Sarang,
Kaul Anpurna,
Khan Beenish,
Ahmad Sheikh Fayaz,
Suri K. A.,
Gupta B. D.,
Satti N. K.,
Qazi G. N.
Publication year - 2006
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1852
Subject(s) - lupeol , pharmacognosy , t lymphocyte , biology , traditional medicine , immunology , biological activity , medicine , immune system , in vitro , genetics
Abstract Lupeol has been shown to possess antiarthritic activity through possible suppression of the immune system. As seen in the following studies, it was found to suppress various immune factors such as the phagocytic (cell‐killing) activity of macrophages, T‐lymphocyte activity that included CD4+T cell mediated cytokine generation. Assessment of T cells and their intracellular content of cytokines was carried out by flow cytometric analysis in Balb/c mice. Oral administration of lupeol at doses of 12.5–200 mg/kg p.o. inhibited CD4+ T and CD8+ T cell counts and cytokines IL‐2, IFN‐ γ (Th1) and IL‐4 (Th2). Cytometric bead array (CBA) technology was applied to carry out simultaneous measurement of multiple serum cytokines. The oral LD 0 in mice was more than 2 g/kg body weight. Copyright © 2006 John Wiley & Sons, Ltd.