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Screening of Thai medicinal plant extracts and their active constituents for In Vitro antimalarial activity
Author(s) -
Ichino C.,
Soonthornchareon N.,
Chuakul W.,
Kiyohara H.,
Ishiyama A.,
Sekiguchi H.,
Namatame M.,
Otoguro K.,
Omura S.,
Yamada H.
Publication year - 2006
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1850
Subject(s) - traditional medicine , plasmodium falciparum , medicinal plants , biology , pharmacognosy , in vitro , malaria , botany , biological activity , medicine , biochemistry , immunology
To discover antimalarial substances from plants cultivated in Thailand 80%‐EtOH extracts from selected plants were screened for in vitro antimalarial activity against the drug resistant K1 strain of Plasmodium falciparum . In total, 86 Thai medicinal plant samples representing 48 species from 35 genera in 16 families were screened and two species ( Polyalthia viridis and Goniothalamus marcanii ) were found to show notable antimalarial activity (IC 50 : 10.0 and 6.3 µg/mL). Marcanine A and 16‐hydroxycleroda‐3,13(14)Z‐dien‐15,16‐olide were identified as the respective major active constituents in P. viridis and G. marcanii , respectively. Copyright © 2006 John Wiley & Sons, Ltd.