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Effects of two Prunella species on lymphocyte proliferation and nitric oxide production
Author(s) -
Harput U. Sebnem,
Saracoglu Iclal,
Ogihara Yukio
Publication year - 2006
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1805
Subject(s) - prunella vulgaris , nitric oxide , splenocyte , lipopolysaccharide , cytotoxicity , in vitro , t lymphocyte , immunology , lymphocyte , biology , traditional medicine , pharmacology , chemistry , biochemistry , medicine , endocrinology , pathology , alternative medicine , traditional chinese medicine
Abstract Water extracts of Prunella vulgaris and P. laciniata have been investigated for their immunomodulatory and antiinflammatory activities concerning their effect on the mitogenic response of murine splenocytes and nitric oxide production by murine peritoneal macrophages in vitro . It was found that both extracts stimulated the proliferation of T‐lymphocytes and suppressed NO production in lipopolysaccharide‐stimulated macrophages dose dependently without any cytotoxicity. Copyright © 2006 John Wiley & Sons, Ltd.