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Antiviral properties of ent‐labdene diterpenes of Andrographis paniculata nees, inhibitors of herpes simplex virus type 1
Author(s) -
Wiart C.,
Kumar K.,
Yusof M. Y.,
Hamimah H.,
Fauzi Z. M.,
Sulaiman M.
Publication year - 2005
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1765
Subject(s) - andrographis paniculata , andrographolide , herpes simplex virus , cytotoxicity , traditional medicine , virology , pharmacognosy , diterpene , virus , biology , pharmacology , chemistry , stereochemistry , medicine , biological activity , in vitro , biochemistry , alternative medicine , pathology
Abstract Andrographolide, neoandrographolide and 14‐deoxy‐11,12‐didehydroandrographolide, ent‐labdene diterpenes isolated from Andrographis paniculata showed viricidal activity against herpes simplex virus 1 (HSV‐1). None of these compounds exhibited significant cytotoxicity at viricidal concentrations. Copyright © 2005 John Wiley & Sons, Ltd.