Premium
Evaluation of antinociceptive and antiinflammatory activities of the essential oil (EO) of Ocimum micranthum Willd. from Northeastern Brazil
Author(s) -
Lino C. S.,
Gomes P. B.,
Lucetti D. L.,
Diógenes J. P. L.,
Sousa F. C. F.,
Silva M. G. V.,
Viana G. S. B.
Publication year - 2005
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1737
Subject(s) - carrageenan , (+) naloxone , ocimum , nociception , chemistry , traditional medicine , analgesic , nitric oxide , pharmacology , opioid , essential oil , medicine , biochemistry , food science , receptor , organic chemistry
The EO of Ocimum micranthum was studied for a possible analgesic effect on the acetic acid induced writhing and formalin test in mice and antioedema activities on the carrageenan and dextran induced paw oedema in rats. The EO demonstrated antinociceptive effects, and pretreatment with naloxone did not reverse the antinociception, indicating that the opioid system is not involved. On the other hand, pretreatment with l ‐arginine ( l ‐arg) reversed the antinociception, suggesting involvement of the nitric oxide (NO) system. The EO did not present an antioedematogenic effect in the carrageenan and dextran models. Copyright © 2005 John Wiley & Sons, Ltd.