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Hypotensive activity and toxicology of constituents from root bark of Polyalthia longifolia var. pendula
Author(s) -
Saleem Rubeena,
Ahmed Muhammad,
Ahmed Syed Iqbal,
Azeem Mohammad,
Khan Rashid Ali,
Rasool Najma,
Saleem Hina,
Noor Fatima,
Faizi Shaheen
Publication year - 2005
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1732
Subject(s) - bark (sound) , traditional medicine , pharmacognosy , biology , botany , medicine , biological activity , in vitro , ecology , biochemistry
A defatted extract of Polyalthia longifolia var. pendula root bark (PRB) in 50% methanol showed a significant ability to reduce blood pressure. It caused a 22% and 47% fall in mean arterial blood pressure (MABP) in rats at doses of 3 mg/kg and 30 mg/kg, respectively. Compounds purified from this extract include kolavenic acid (3), clerodane (1) and its isomer (2), liriodenine (4), lysicamine (5) and bisclerodane imide (6) and its isomer (7). Of these, only kolavenic acid produced a 22% fall in MABP, at a dose of 30 mg/kg. PRB showed a decrease in blood pressure of normotensive and egg yolk induced hypertensive rats. The LD 50 of PRB was determined as 100 mg/kg in mice. Copyright © 2005 John Wiley & Sons, Ltd.