Premium
Antitubercular sterols from Thalia multiflora Horkel ex Koernicke
Author(s) -
GutierrezLugo MariaTeresa,
Wang Yuehong,
Franzblau Scott G.,
Suarez Enrique,
Timmermann Barbara N.
Publication year - 2005
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1731
Subject(s) - isorhamnetin , sterol , flavonoid , chemistry , quercetin , traditional medicine , glycoside , botany , stereochemistry , biology , organic chemistry , biochemistry , antioxidant , medicine , kaempferol , cholesterol
Bioassay guided isolation of an antitubercular extract of the aerial parts of Thalia multiflora led to the isolation of nine stigmast‐5‐ene and stigmasta‐5,22‐dien steroids, four isorhamnetin and quercetin flavonoid glycosides, two ceramides, an indole alkaloid and two simple phenolic compounds. Stigmast‐5‐en‐3 β ‐ol‐7‐one (2), stigmast‐4‐ene‐6 β ‐ol‐3‐one (3), stigmast‐5,22‐dien‐3 β ‐ol‐7‐one (7) and stigmast‐4,22‐dien‐6 β ‐ol‐3‐one (8) were found to be the most active compounds with MIC values of 1.98 ± 0.02, 4.2 ± 0.17, 1.0 ± 0.06 and 2.2 ± 0.3 µg/mL, respectively. Compounds 2, 3, 7 and 8 were not cytotoxic to Vero cells at 102 µg/mL. This investigation constitutes the first report of a chemical study of a species of the genus Thalia. Copyright © 2005 John Wiley & Sons, Ltd.