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Cytotoxic activities of ethyl acetate extract and a metabolite from a Monocillium species
Author(s) -
Khondkar Proma,
Rahman M. Mukhlesur,
Islam Anwarul
Publication year - 2005
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1730
Subject(s) - brine shrimp , ethyl acetate , bioassay , metabolite , chemistry , shrimp , cytotoxic t cell , traditional medicine , chromatography , biology , in vitro , biochemistry , medicine , fishery , genetics
Abstract The ethyl acetate soluble fraction of a cultural broth of a Monocillium species afforded the isolation of 5‐hydroxymethylfurfural. Both the extract and 5‐hydroxymethylfurfural showed significant cytotoxic activities in a brine shrimp bioassay and the LC 50 values were found to be 14.96 µg/mL and 23.71 µg/mL, respectively. Copyright © 2005 John Wiley & Sons, Ltd.