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Wound healing properties of Hylocereus undatus on diabetic rats
Author(s) -
Perez G. R. M.,
Vargas S. R.,
Ortiz H. Y. D.
Publication year - 2005
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1724
Subject(s) - hydroxyproline , wound healing , breaking strength , ultimate tensile strength , granulation tissue , traditional medicine , chemistry , botany , medicine , biology , surgery , materials science , biochemistry , metallurgy , composite material
Aqueous extracts of leaves, rind, fruit pulp and flowers of Hylocereus undatus were studied for their wound healing properties. Wound healing effects were studied on incision (skin breaking strength), excision (percent wound contraction) and the nature of wound granulation tissues, which were removed on day 7 and the collagen, hexosamine, total proteins and DNA contents were determined, in addition to the rates of wound contraction and the period of epithelialization. In streptozotocin diabetic rats, where healing is delayed, topical applications of H. undatus produced increases in hydroxyproline, tensile strength, total proteins, DNA collagen content and better epithelization thereby facilitating healing. H. undatus had no hypoglycemic activity. Copyright © 2005 John Wiley & Sons, Ltd.