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Additional antiprotozoal constituents from Cuphea pinetorum , a plant used in Mayan traditional medicine to treat diarrhoea
Author(s) -
Calzada Fernando
Publication year - 2005
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1717
Subject(s) - antiprotozoal , kaempferol , apigenin , traditional medicine , phytochemical , flavonoid , tricin , luteolin , quercetin , glycoside , biology , chemistry , pharmacology , stereochemistry , botany , medicine , biochemistry , in vitro , antioxidant
In addition to kaempferol and quercetin already found in the roots from Cuphea pinetorum , bioassay‐guided fractionation of the crude extract of the aerial part of this species gave four flavonoid glycosides, quercetin‐3‐ O ‐ α ‐rhamnopyranoside, luteolin‐7‐ O ‐ β ‐ d ‐glucopyranoside, apigenin‐7‐ O ‐ α ‐ l ‐rhamnopyranoside and apigenin‐7‐ O ‐ β ‐ d ‐glucopyranoside, as well as squalen and β ‐sitosterol. In vitro antiamoebic and antigiardial activities of isolated compounds indicated that kaempferol is the principal antiprotozoal agent in C. pinetorum . Based on finding this antiprotozoal inhibitor, flavonoids were studied in order to elucidate structure‐activity relationships. These data suggest that kaempferol may play an important role in antidiarrhoeal activity of C. pinetorum . Copyright © 2005 John Wiley & Sons, Ltd.