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Studies on antidiarrhoeal activity of an extract of wine from Jacquez grapes in mice
Author(s) -
Vitali Federica,
Bonina Francesco P.,
Saija Antonella,
Tomaino Antonio,
Fonte Giuseppina,
Pennisi Claudia,
Tita Beatrice
Publication year - 2005
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1707
Subject(s) - antidiarrhoeal , wine , traditional medicine , meal , vitaceae , castor oil , malpighiaceae , food science , activated charcoal , charcoal , vitis vinifera , biology , medicine , botany , chemistry , biochemistry , organic chemistry , adsorption
The present study was designed to verify the antidiarrhoeal effects of a lyophilized extract of wine from Jacquez grapes (Ord. Rhamnales ; Fam. Vitaceae ; Sp. Vitis aestivalis M.‐ cinerea E. × Vitis vinifera L.), studying its influence on castor oil‐induced diarrhoea and enteropooling, and on gastrointestinal transit (measured by a charcoal marker) in mice. The pre‐treatment of the animals with the JWE ( Jacquez wine extract) produced a significant inhibition against castor oil induced‐diarrhoea and intestinal fluid accumulation; furthermore the extract significantly decreased the propulsive movement of the charcoal meal. These findings suggest a potential benefical use of the JWE in the treatment of diarrhoeal diseases. Copyright © 2005 John Wiley & Sons, Ltd.