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Inhibition of cyclo‐oxygenase‐2 expression in mouse macrophages by 4‐(3‐methyl‐but‐1‐enyl)‐3,5,3′,4′‐tetrahydroxystilbene, a resveratrol derivative from peanuts
Author(s) -
Patel Bankim,
Patel Sandip,
Hoffman Richard
Publication year - 2005
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1698
Subject(s) - resveratrol , oxygenase , chemistry , heme oxygenase , derivative (finance) , biochemistry , stereochemistry , pharmacology , enzyme , biology , heme , financial economics , economics
Resveratrol derivatives are of interest as inhibitors of cyclo‐oxygenase‐2 and as antiinflammatory agents. The prenylated resveratrol derivative 4‐(3‐methyl‐but‐1‐enyl)‐3,5,3′,4′‐tetrahydroxystilbene was purified from fungally infected peanuts by thin layer chromatography and its structure was confirmed by mass spectrometry. 4‐(3‐Methyl‐but‐1‐enyl)‐3,5,3′,4′‐tetrahydroxystilbene inhibited lipopolysaccharide‐induced expression of cyclo‐oxygenase‐2 protein and cyclo‐oxygenase‐2 mRNA in mouse macrophages at concentrations that were non‐cytotoxic. 4‐(3‐Methyl‐but‐1‐enyl)‐3,5,3′,4′‐tetrahydroxystilbene warrants further evaluation as an antiinflammatory agent. Copyright © 2005 John Wiley & Sons, Ltd.