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Antioxidant activity of ethanol extract of Callophyllis japonica
Author(s) -
Kang Kyoung Ah,
Bu Hyung Deuk,
Park Dal Soo,
Go Gyung Min,
Jee Youngheun,
Shin Taekyun,
Hyun Jin Won
Publication year - 2005
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/ptr.1692
Subject(s) - antioxidant , catalase , superoxide dismutase , dpph , lipid peroxidation , reactive oxygen species , chemistry , biochemistry , traditional medicine , biology , medicine
The antioxidant properties of the red seaweed Callophyllis japonica were investigated. An ethanol extract isolated from C. japonica exhibited intracellular reactive oxygen species, 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) radical scavenging activity and lipid peroxidation inhibitory activity. The radical scavenging activity of the extract protected the viability of Chinese hamster lung fibroblast (V79‐4) cells exposed to H 2 O 2 . Furthermore, the extract reduced the proportion of apoptotic cells induced by H 2 O 2 , as demonstrated by decreased sub‐G 1 hypo‐diploid cells and decreased apoptotic body formation. The extract also increased the activities of the cellular antioxidant enzymes, superoxide dismutase and catalase. Together, these findings suggest that C. japonica exhibits antioxidant properties. Copyright © 2005 John Wiley & Sons, Ltd.